Posted June 15, 2010 by Editor in Molecular Biology | No comments yet
Could new university research study reveals a novel mechanism for New Hair formulation, Lead Discovery TS050508A for more effective treatments Dateline: Rensselaer, NY 20 August 2009 In the current issue of the peer-reviewed medical journal Evidence Based Complimentary &; Alternative Medicine (ECAM) Scientists at the University of Albany Center for Functional Genomics, works together with Advanced Restoration Technologies (ART), to report the positive results of a series of basic scientific experiments conducted recently to test a novel, naturally derived hair loss treatment formula TS050508A. Because chronic inflammation of the hair follicle as a factor in the onset and progression of androgenetic alopecia (AGA), sought investigators Sridar Chittur, Brian Parr & Geno Marcovici to the test material activity in blocking key markers of pathological inflammation by measuring with the help of a well-validated molecular Assay representatives of the hair follicle keratinocytes. Specifically, the research team found that the substance suppresses gene expression of several inflammatory chemokines may be linked to hair loss. In addition, anti-inflammatory agents, was TS050508A with a subset of botanically derived, highly potent 5-alpha reductase (5AR) inhibitors formulated. 5AR catalyzes the conversion of testosterone (T) to its more pathological metabolite dihydrotestosterone (DHT). DHT is a known cause of hair loss. So, the combination of a targeted anti-inflammatory substances with potent inhibitors of 5AR the test composition is designed to offer improved clinical efficacy compared with conventional monotherapy. Chief scientist of the study Sridar Chittur Ph. D. at the forefront of molecular research ranges authoring published works of degenerative mitral regurgitation (DMVD), the transcriptional changes associated with oxidative stress in the mitochondria. Co-author Brian Parr, Ph.D. brings a wealth of fundamental scientific expertise to the project with a series of peer-reviewed papers novel transcription and protein expression profiles described in the Wnt and Frizzled signaling pathways. Co-author of the study Geno Marcovici, Ph. D. has been active in the hair loss area for more than a decade. His research includes the first published clinical study successfully tested naturally derived 5-alpha reductase inhibitors in the setting of hair loss. Discusses the importance of validation of ART’s proprietary formulations Marcovici notes that “® [a] page of HairGenesis, the naturally-derived hair treatments commercially available offer little or no objective evidence that they work. On the other hand, drug treatments, tends not to work with potentially serious side effects occur. HairGenesis make this a unique offering ® in this category. “About ECAM with a reference cited factor of 2 535, the international, peer-reviewed journal Evidence-based Complementary and Alternative Medicine (ECAM) is widely publications are in the category of the ISI Integrative & Complementary Medicine as one of the most respected research. The journal aims to apply scientific rigor to the study of complementary and alternative medicine (CAM) modalities. ECAM emphasizes health outcome, while the documentation of biological mechanisms of action. The journal is dedicated to the advancement of science in basic research, clinical studies, methodology or scientific theory in diverse fields of biomedical sciences. ECAM is also noteworthy as a magazine that published the final version of every NIH-funded paper publicly available in PubMed Central no later than 12 months after publication. Such deposits are in accordance with the NIH Public Access Policy. Link to New Hair Growth Formula Study http://ecam. oxford journals. org/cgi/content/full/nep102? ijkey JY5szXDPsjpHFxm = & ref = KeyType About the Center for Functional Genomics Microarray Core Facility SUNY a component of the University of Albany Center for Functional Genomics, and was founded to enable the infrastructure to offer the development of major projects that use DNA microarrays for large-scale analysis of gene expression. The DNA Microarray Center currently employs two technologies for gene expression analysis: Affymetrix GeneChip arrays and custom-made spotted cDNA microarrays. Projects by the DNA Microarray Center developed made use Affymetrix arrays, both eukaryotic and prokaryotic genomes. The facility is also currently specializes in developing custom printed arrays to study gene expression in tissues of the mouse, as part of an NIH-funded Mutant Mouse Regional Resource Center. # # # About Advanced Restoration Technologies, Inc., DBA HairGenesis ® combined with scientific validation of the safety of natural ingredients, ART is a unique product line HairGenesis ® platform in the therapeutic treatment for hair loss category. Previously focused on basic research, the established art as a 10-year track record as a surgical center for IRB monitored clinical research, testing new drugs and medical devices. ART-based published studies include those committed in the name of Organogenesis, Canton, MA and procytes Corporation, Kirkland, WA. It was from this research platform, the hair Genesis ™ was originally conceived and created. Hair Genesis ® is notable as the first, and only naturally derived hair loss treatment published by 3rd party support clinical and basic research. Hair Genesis ® is sold primarily through Internet-based distribution. Distributors of Genesis ® Hair onlyhairloss belong. com, hairlosswatch. com, & hairgenesisasia. com. For further information contact: â € · Geno Marcovici, Ph. D. Advanced Restoration Technologies, Inc., DBA Hair Genesis ® dr. Marcovici @ hairgenesis. com http://www. hairgenesis. com
